Transcription-Coupled Structural Dynamics of Topologically Associating Domains Regulate Replication Origin Efficiency
نویسندگان
چکیده
منابع مشابه
Structural Fluctuations of the Chromatin Fiber within Topologically Associating Domains.
Experiments based on chromosome conformation capture have shown that mammalian genomes are partitioned into topologically associating domains (TADs), within which the chromatin fiber preferentially interacts. TADs may provide three-dimensional scaffolds allowing genes to contact their appropriate distal regulatory DNA sequences (e.g., enhancers) and thus to be properly regulated. Understanding ...
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Metazoan genomes are organized into regions of topologically associating domains (TADs). TADs are demarcated by border elements, which are enriched for active genes and high occupancy architectural protein binding sites. We recently demonstrated that 3D chromatin architecture is dynamic in response to heat shock, a physiological stress that downregulates transcription and causes a global redist...
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Rapidly evolving in humans topologically associating domains Gennadi V. Glinsky 2 1 Institute of Engineering in Medicine University of California, San Diego 9500 Gilman Dr. MC 0435 La Jolla, CA 92093-0435, USA Correspondence: [email protected] Web: http://iem.ucsd.edu/people/profiles/guennadi-v-glinskii.html The Stanford University School of Medicine, Medical School Lab Surge Bldg., Room P214,...
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Recent chromosome conformation capture (3C) derived techniques have revealed that topologically associating domain (TAD) is a pervasive element in chromatin three-dimensional (3D) organization. However, there is currently no parameter to quantitatively measure the structural characteristics of TADs, thus obscuring our understanding on the structural and functional differences among TADs. Based ...
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ژورنال
عنوان ژورنال: SSRN Electronic Journal
سال: 2020
ISSN: 1556-5068
DOI: 10.2139/ssrn.3554081